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Silvestrol aglycone
CAS No. 960365-65-5
Silvestrol aglycone ( —— )
产品货号. M16856 CAS No. 960365-65-5
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥6391 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Silvestrol aglycone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
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产品描述Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis
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研究领域Cancer
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适应症——
化学信息
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CAS Number960365-65-5
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分子量478.49
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分子式C27H26O8
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCOC1=CC=C(C=C1)C23C(C(C(C2(C4=C(O3)C=C(C=C4OC)O)O)O)C(=O)OC)C5=CC=CC=C5
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化学全称1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.
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